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I have a friend who has heart failure from idiopathic cardiomyopathy.He is already on Coq10 & has recently undergone biventricular pacing.I checked on the net about the use of injectable Testosterone in heart failure but have'nt found details regarding dosage etc.If any of you have any information regarding this,please let me know.

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Comment by Dr Anoop Chaturvedi on February 20, 2011 at 7:06pm

Front Horm Res. 2009;37:183-96.

Testosterone in chronic heart failure.

Malkin CJ, Jones TH, Channer KS.

Department of Cardiology, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK. Chris.malkin@sth.nhs.uk

Abstract

Chronic heart failure is common and can be described as a syndrome characterized by impairment of cardiac function associated with a maladaptive metabolic and neurohormonal axis. The thesis that testosterone replacement therapy may be helpful as a treatment for chronic heart failure may seem at first to be unlikely. Testosterone therapy is widely believed to be deleterious to the cardiovascular system and there is a common misconception that the excess of ischaemic heart disease in young and middle-aged males compared to females is a direct effect of endogenous serum testosterone levels. In this chapter we will present the published evidence of the effects of endogenous and therapeutic testosterone on the heart and the human cardiovascular system with an emphasis on the pathologic syndrome of chronic heart failure. There is developing evidence that of all morbid populations, patients with chronic heart failure in particular are likely to benefit from testosterone treatment since the natural history is that of progressive disordered metabolism with catabolic excess and androgen imbalance.

PMID: 19011297 [PubMed - indexed for MEDLINE]

Comment by Dr Anoop Chaturvedi on February 20, 2011 at 6:51pm

J Cardiovasc Pharmacol Ther. 2011 Mar;16(1):14-23. Epub 2010 Nov 19.

Review: testosterone therapy: treatment of metabolic disturbances in heart failure.

Naghi JJ, Philip KJ, Dilibero D, Willix R, Schwarz ER.

Cedars-Sinai Heart Institute, Comprehensive Transplant Program, Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Abstract

Heart failure (HF) is a complex progressive multisystem disease state with significant morbidity and mortality, which is not solely defined by pathology of the cardiovascular system but also is influenced by neurohormonal regulatory adjustments, peripheral cytokines, as well as hormonal and musculoskeletal dysfunction. Recent attention to the catabolic state found in patients with chronic heart failure has sparked interest in new potential targets for medical therapy. In particular, as many as 26% to 37% of men affected with HF have been found to be testosterone deficient. The severity of androgen deficiency has been shown to correlate with symptoms, functional class, and prognosis in patients with heart failure. Testosterone supplementation has been an accepted therapy in hypogonadal men with fatigue, muscle wasting, and se

Comment by Dr Deepak Chaturvedi on July 1, 2010 at 10:53pm
Hello Dr. Shabnam. Testosterone do help in cardiomyopathy. It does not have much role in acute setting but improves the prognosis in long term. Kindly evaluate the liver profile , testosterone level (total and free), SHBG , Thyroid profile , DHEA , Cortisol , VIt B12 , Iron studies. Need to know the current cardiac status. Kindly feel free to call on my number 9987002515

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